Mechanism of the effect of atorvastatin calcium
Atorvastatin is a selective and competitive inhibitor of HMG-CoA reductase, which reduces the levels of cholesterol and lipoprotein in plasma by inhibiting the synthesis of HMG-CoA reductase and cholesterol in the liver, and enhances LDL uptake and metabolism by increasing the cell's indication of the liver.
Atorvastatin reduces LDL cholesterol formation and low-density lipoprotein cholesterol particles. Atorvastatin results in a significant and persistent increase in LDL-cholesterol receptor activity, and in turn circulating low density lipoprotein cholesterol granules in the treatment of beneficial changes. Atorvastatin can effectively reduce the low density lipoprotein level in patients with familial hypercholesterolemia, and usually reduce the efficacy of lipid-lowering drugs in such patients.